Now recruiting in Perth

Is perimenopause affecting your quality of life?

Researchers at Clinical Research Australia are investigating whether a probiotic supplement can improve quality of life during perimenopause.

You may be eligible if you are aged 40–55, have experienced changes in your menstrual cycle, and have ongoing perimenopausal symptoms affecting your quality of life.

Check if you’re eligible Read the information sheet

Online questionnaire takes 5–10 minutes · Confidential · No obligation

Perimenopause can feel different for everyone

Are you experiencing changes such as:

✓Changes in mood

✓Poor sleep

✓Low energy or fatigue

✓Difficulty concentrating

✓Hot flushes or night sweats

✓Changes in libido

✓Digestive symptoms

✓Joint discomfort

✓Reduced overall wellbeing

You do not need to experience all these symptoms to apply.

About the research

A rigorous study of perimenopausal wellbeing

Preliminary research suggests probiotics may help with symptoms experienced during the menopausal transition. This study will investigate whether a probiotic called LactoSpore® can improve menopause-related quality of life, including mood, sleep, energy, concentration, vasomotor symptoms, libido, digestion, joint comfort and overall wellbeing.

Blood markers that may be associated with perimenopausal symptoms will also be measured. This is an ethics-approved, randomised, double-blind, placebo-controlled clinical trial. Half of participants will receive LactoSpore® and half will receive placebo capsules.

What participation involves

Your participation at a glance

Start eligibility check →

Apply online

Complete a confidential eligibility questionnaire (5–10 minutes).

Telephone interview

A researcher will discuss the study and assess your eligibility (about 10 minutes).

Visit our Duncraig clinic

Attend two assessment visits—at baseline and week 12 (about 30 minutes each).

Complete two fasting blood tests

Samples are collected at a Western Diagnostics Pathology clinic at baseline and week 12.

Take study capsules

Take one probiotic or placebo capsule daily for 12 weeks.

Complete online questionnaires

Complete brief questionnaires online at weeks 4 and 8 (about 10 minutes).

Who may be suitable?

You may be eligible if:

You are a woman aged 40–55 years
Your menstrual cycle has changed for at least two months
Perimenopausal symptoms are affecting your quality of life
You are generally healthy and a non-smoker
You can attend two appointments in Duncraig
You are willing to take one capsule daily for 12 weeks

Ethics approvedNIIM Ethics Committee
Ref. 0164E_2026

Registered trialAustralian & New Zealand
Clinical Trials Registry

Experienced team5,000+ participants
in past studies

ConfidentialVoluntary participation
and protected details

Take the first step

Could this study be right for you?

Complete the short, confidential questionnaire to help our research team assess your eligibility. Applying does not commit you to taking part.