Our Published Clinical Trials
Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study. J Psychoactive Drugs. 2024 Nov 5:1-13. Authors: Sanjiv Kale, Adrian Lopresti, Ravleen Suri, et al. Click here for a link to the article
An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. June 2024. Authors: Adrian Lopresti, Stephen Smith, Melissa Riggs, et al. Click here for a link to the article
Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. Nov 2023. Authors: Stephen Smith, Adrian Lopresti, and Timothy Fairchild. Click here for a link to the article
A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (Holixer) on stress, mood, and sleep in adults experiencing stress. Frontiers in Nutrition. September 2022. Authors: Adrian Lopresti, Stephen Smith, Alexandra Metse and Peter Drummond. Click here for a link to the article
An examination into the mental and physical effects of a saffron extract (affron®) in recreationally-active adults: A randomized, double-blind, placebo-controlled study. Journal of the International Society of Sports Nutrition. June 2022. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article
Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study. Journal of Functional Foods. October 2021. Authors: Adrian Lopresti, Stephen Smith, Sinan Ali, Alexandra Metse, John Kalns, and Peter Drummond. Click here for a link to the article
An investigation into the anxiety-relieving and mood-enhancing effects of Echinacea angustifolia (EP107™): A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders. October 2021. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article
The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. Journal of Menopausal Medicine. August 2021. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article
The Feasibility and Efficacy of a Brief Integrative Treatment for Adults With Depression and/or Anxiety: A Randomized Controlled Trial. Journal of Evidence-Based Integrative Medicine. July 2020. Authors: Adrian Lopresti, Stephen Smith, Alexandra Metse, Tiffany Foster, and Peter Drummond. Click here for a link to the article
Efficacy of a standardised saffron extract (affron®) as an add-on to antidepressant medication for the treatment of persistent depressive symptoms in adults: A randomised, double-blind, placebo-controlled study. Journal of Psychopharmacology. September 2019. Authors: Adrian Lopresti, Stephen Smith, Sean Hood, and Peter Drummond. Click here for a link to the article
An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine. September 2019. Authors: Adrian Lopresti, Stephen Smith, Kakeemudin, Malvi, and Rahul Kodgule. Click here for a link to the article
affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders. May 2018. Authors: Adrian Lopresti, Peter Drummond, Antonio Inarejos-García, and Marin Prodanov. Click here for a link to the article
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders. January 2017. Authors: Adrian Lopresti and Peter Drummond. Click here for a link to the article
The effects of lutein/ zeaxanthin (Lute-gen®) on eye health, eye strain, sleep quality, and attention in high electronic screen users: a randomized, double-blind, placebo-controlled study. Front. Nutr. 2025, Volume 12. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article
Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study. J Psychoactive Drugs. 2024 Nov 5:1-13. Authors: Sanjiv Kale, Adrian Lopresti, Ravleen Suri, et al. Click here for a link to the article
An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. June 2024. Authors: Adrian Lopresti, Stephen Smith, Melissa Riggs, et al. Click here for a link to the article
Effects of a polyphenol-rich grape and blueberry extract (Memophenol™) on cognitive function in older adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study. Frontiers in Psychology 2023. Authors: Adrian Lopresti, Stephen Smith, Camille Pouchieu, Line Pourtau, David Gaudout, Véronique Pallet, and Peter Drummond. Click here for a link to the article
The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study. Frontiers in Nutrition. February 2022. Authors: Adrian Lopresti, Stephen Smith, and Peter Drummond. Click here for a link to the article
Effects of an Oroxylum indicum Extract (Sabroxy®) on Cognitive Function in Adults With Self-reported Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Study. Frontiers in Aging Neuroscience. August 2021. Authors: Adrian Lopresti, Stephen Smith, Muhammed Majeed, and Peter Drummond. Click here for a link to the article
The effects of lutein/ zeaxanthin (Lute-gen®) on eye health, eye strain, sleep quality, and attention in high electronic screen users: a randomized, double-blind, placebo-controlled study. Front. Nutr. 2025, Volume 12. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article
A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (Holixer) on stress, mood, and sleep in adults experiencing stress. Frontiers in Nutrition. September 2022. Authors: Adrian Lopresti, Stephen Smith, Alexandra Metse and Peter Drummond. Click here for a link to the article
An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study. Sleep Medicine. October 2021. Authors: Adrian Lopresti, Stephen Smith, and Peter Drummond. Click here for a link to the article
Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study. Journal of Functional Foods. October 2021. Authors: Adrian Lopresti, Stephen Smith, Sinan Ali, Alexandra Metse, John Kalns, and Peter Drummond. Click here for a link to the article
Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. Journal of Clinical Sleep Medicine. June 2020. Authors: Adrian Lopresti, Stephen Smith, Alexandra Metse, and Peter Drummond. Click here for a link to the article
Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study. J Psychoactive Drugs. 2024 Nov 5:1-13. Authors: Sanjiv Kale, Adrian Lopresti, Ravleen Suri, et al. Click here for a link to the article
Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. Nov 2023. Authors: Stephen Smith, Adrian Lopresti, and Timothy Fairchild. Click here for a link to the article
An examination into the mental and physical effects of a saffron extract (affron®) in recreationally-active adults: A randomized, double-blind, placebo-controlled study. Journal of the International Society of Sports Nutrition. June 2022. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article
Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study. Journal of Functional Foods. October 2021. Authors: Adrian Lopresti, Stephen Smith, Sinan Ali, Alexandra Metse, John Kalns, and Peter Drummond. Click here for a link to the article
A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males. American Journal of Men's Health. March 2019. Authors: Adrian Lopresti, Peter Drummond, and Stephen Smith. Click here for a link to the article
Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study. BMC Complementary Medicine and Therapies. January 2021. Authors: Adrian Lopresti, Stephen Smith, Alethea Rea, and Shavon Jackson-Michel. Click here for a link to the article
A poly-herbal blend (Herbagut®) on adults presenting with gastrointestinal complaints: a randomised, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018 Mar 20;18(1):98. Authors: Adrian Lopresti, Hemant Gupta, & Stephen Smith Click here for a link to the article
The effects of lutein/ zeaxanthin (Lute-gen®) on eye health, eye strain, sleep quality, and attention in high electronic screen users: a randomized, double-blind, placebo-controlled study. Front. Nutr. 2025, Volume 12. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article
An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. June 2024. Authors: Adrian Lopresti, Stephen Smith, Melissa Riggs, et al. Click here for a link to the article
An Investigation into the Effects of a Curcumin Extract (Curcugen®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study. Nutrients 2022, 14(1), 41. Authors: Adrian Lopresti, Stephen Smith, Shavon Jackson-Michel, and Timothy Fairchild. Click here for a link to the article
The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. Journal of Menopausal Medicine. August 2021. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article
A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males. American Journal of Men's Health. March 2019. Authors: Adrian Lopresti, Peter Drummond, and Stephen Smith. Click here for a link to the article