This study is only available for people able to travel to our office in Duncraig, WA 6023

Khaya senegalensis is a tree species native to Africa (and now also cultivated in Australia). Common names include African mahogany, dry zone mahogany, Gambia mahogany, khaya wood, and Senegal mahogany. Khaya senegalensis has traditionally been used to treat menstruation pain, dysmenorrhoea, ovulation disturbances, and digestive pain and discomfort. In this study, we are interested in investigating its effects on menopausal symptoms in peri- and post-menopausal women experiencing menopausal symptoms.

If you are a female aged between 42 and 62 years and experience symptoms that may be associated with the menopausal transition, we invite you to participate in this randomised, controlled study.

PLEASE NOTE: NO travel to our office is required for this study, as all questionnaires are completed online. However, a blood sample will need to be collected at your nearest Australian Clinical Labs collection centre.

Eligible participants will be RANDOMLY allocated into ONE of TWO treatment conditions:

1. Daily intake of tablets containing Khaya senegalensis (Khapregesic), or
2. Daily intake of placebo (fake) tablets

This 4-week study consists of the following:

1.Participate in a 10-minute phone interview to discuss the study and assess your eligibility to participate.
2.Take the tablets for 4 weeks (2 tablets 2 times daily, containing either placebo or Khaya senegalensis).
3.Complete online questionnaires 2 and 4 weeks after you have been taking the tablets. These will take 10 to 15 minutes to complete
4.Have a blood sample collected at your nearest Western Diagnositics Pathology Collection Centre at the beginning and end of the study

You can download the full STUDY INFORMATION SHEET by clicking the button on this webpage

To compensate you for your time and travel involved in this study, at the end of the study, we will send you a $120 gift voucher. People placed on the placebo will also be given a free 4-week supply of Khaya senegalensis tablets when this study is completed.

To be INCLUDED in the study, the following inclusion criteria must be met:

1. You are a women aged 42 to 62 years
2. You have an intact uterus and ovaries
3. You are experiencing menopausal/ climactic symptoms for at least 3 months
4. You have not experienced a period in the last 12 months; OR for at least 3 months you have experienced changes in your menstrual cycle (e.g., bleeding days, heaviness of bleeding, or days between menses)
5. You are a non-smoker
6. You have a BMI between 18 and 30 kg/m2
7. You have no plan to commence new treatments over the study period.
8. You understand and are willing and able to comply with all study procedures.
9. You are willing to provide a personally signed and dated informed consent form detailing all pertinent aspects of the trial.

If any of the exclusion criteria below are met, the applicant will not be suitable for participation in this study:

1. You suffer from recently diagnosed or unmanaged medical conditions including but not limited to: diabetes, hypertension, cardiovascular disease, gastrointestinal disease requiring regular use of medications, biliary disease, autoimmune disease, cancer/malignancy, endocrine disease, or chronic/acute pain condition.
2. You are diagnosed with neurological or psychiatric conditions including but not limited to: psychiatric disorder (other than mild-to-moderate depression or anxiety), Parkinson’s disease, Alzheimer’s disease, intracranial haemorrhage, or head injury.
3. In the last 3 months, you have commenced or changed pharmaceutical medications that are likely to affect treatment outcomes, or you expect to change medications during the study duration
4. In the last 3 months, you have commenced or changed nutritional or herbal supplements that are likely to affect treatment outcomes, or you expect to change supplements during the study duration
5. You have planned a major lifestyle change in the next 2 months.
6. Your alcohol intake is greater than 14 standard drinks per week
7. You currently (or in the last 12 months) have regularly used illicit drugs
8. You are pregnant, breastfeeding, or intend to fall pregnant during the study period.
9. In the last year, you have had a significant surgery that affected your general health or daily function, or you have a surgery planned in the next 2 months
10. You have participated in another clinical trial in the last month

This study has been approved by the National Institute of Integrative Medicine (NIIM) Ethics Committee (Reference number: 0154E_2025)

If you are interested in participating in this study, please click on the button "Complete the Study Application Form" located on this webpage. This questionnaire will take aproximately 10 minutes to complete and helps us assess your eligibility to participate in this study.

Please Note: All answers are confidential and will only be seen by study investigators. If you are not eligible to participate in this study, your records will be deleted immediately

If you would like to speak to a researcher to get more information about this study, you can call us on 08 9448 7376