Our Published Clinical Trials

The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. Front Nutr. 2026 Jul;12. Authors: Adrian Lopresti and Stephen Smith Click here for a link to the article

The Effects of a Bacopa monnieri Extract (Bacumen®) on Cognition, Stress, and Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Clin Drug Investig. 2025 Jul;45(12):967-982. Authors: Adrian Lopresti and Stephen Smith Click here for a link to the article

An Examination into the Effects of a Saffron Extract (Affron) on Mood and General Wellbeing in Adults Experiencing Low Mood: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Nutrition. 2025 Jul;155(7):2300-2311. Authors: Adrian Lopresti, Stephen Smith, Wolfgang Marx, Marina Díez-Municio, María Inés Morán-Valero. Click here for a link to the article

Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study. J Psychoactive Drugs. 2024 Nov 5:1-13. Authors: Sanjiv Kale, Adrian Lopresti, Ravleen Suri, et al. Click here for a link to the article

An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. June 2024. Authors: Adrian Lopresti, Stephen Smith, Melissa Riggs, et al. Click here for a link to the article

Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. Nov 2023. Authors: Stephen Smith, Adrian Lopresti, and Timothy Fairchild. Click here for a link to the article

A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (Holixer) on stress, mood, and sleep in adults experiencing stress. Frontiers in Nutrition. September 2022. Authors: Adrian Lopresti, Stephen Smith, Alexandra Metse and Peter Drummond. Click here for a link to the article

An examination into the mental and physical effects of a saffron extract (affron®) in recreationally-active adults: A randomized, double-blind, placebo-controlled study. Journal of the International Society of Sports Nutrition. June 2022. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article

Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study. Journal of Functional Foods. October 2021. Authors: Adrian Lopresti, Stephen Smith, Sinan Ali, Alexandra Metse, John Kalns, and Peter Drummond. Click here for a link to the article

An investigation into the anxiety-relieving and mood-enhancing effects of Echinacea angustifolia (EP107™): A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders. October 2021. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article

The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. Journal of Menopausal Medicine. August 2021. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article

The Feasibility and Efficacy of a Brief Integrative Treatment for Adults With Depression and/or Anxiety: A Randomized Controlled Trial. Journal of Evidence-Based Integrative Medicine. July 2020. Authors: Adrian Lopresti, Stephen Smith, Alexandra Metse, Tiffany Foster, and Peter Drummond. Click here for a link to the article

Efficacy of a standardised saffron extract (affron®) as an add-on to antidepressant medication for the treatment of persistent depressive symptoms in adults: A randomised, double-blind, placebo-controlled study. Journal of Psychopharmacology. September 2019. Authors: Adrian Lopresti, Stephen Smith, Sean Hood, and Peter Drummond. Click here for a link to the article

An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine. September 2019. Authors: Adrian Lopresti, Stephen Smith, Kakeemudin, Malvi, and Rahul Kodgule. Click here for a link to the article

affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders. May 2018. Authors: Adrian Lopresti, Peter Drummond, Antonio Inarejos-García, and Marin Prodanov. Click here for a link to the article

Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders. January 2017. Authors: Adrian Lopresti and Peter Drummond. Click here for a link to the article

The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. Front Nutr. 2026 Jul;12. Authors: Adrian Lopresti and Stephen Smith Click here for a link to the article

The Effects of a Bacopa monnieri Extract (Bacumen®) on Cognition, Stress, and Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Clin Drug Investig. 2025 Jul;45(12):967-982. Authors: Adrian Lopresti and Stephen Smith Click here for a link to the article

An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial. Front. Nutr. 2025, Volume 12. Authors: Adrian Lopresti, Stephen Smith, Lixin Ding, Yanmei Li, and Peinan Zhang. Click here for a link to the article

The effects of lutein/ zeaxanthin (Lute-gen®) on eye health, eye strain, sleep quality, and attention in high electronic screen users: a randomized, double-blind, placebo-controlled study. Front. Nutr. 2025, Volume 12. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article

Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study. J Psychoactive Drugs. 2024 Nov 5:1-13. Authors: Sanjiv Kale, Adrian Lopresti, Ravleen Suri, et al. Click here for a link to the article

An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. June 2024. Authors: Adrian Lopresti, Stephen Smith, Melissa Riggs, et al. Click here for a link to the article

Effects of a polyphenol-rich grape and blueberry extract (Memophenol™) on cognitive function in older adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study. Frontiers in Psychology 2023. Authors: Adrian Lopresti, Stephen Smith, Camille Pouchieu, Line Pourtau, David Gaudout, Véronique Pallet, and Peter Drummond. Click here for a link to the article

The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study. Frontiers in Nutrition. February 2022. Authors: Adrian Lopresti, Stephen Smith, and Peter Drummond. Click here for a link to the article

Effects of an Oroxylum indicum Extract (Sabroxy®) on Cognitive Function in Adults With Self-reported Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Study. Frontiers in Aging Neuroscience. August 2021. Authors: Adrian Lopresti, Stephen Smith, Muhammed Majeed, and Peter Drummond. Click here for a link to the article

The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. Front Nutr. 2026 Jul;12. Authors: Adrian Lopresti and Stephen Smith Click here for a link to the article

An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial. Front. Nutr. 2025, Volume 12. Authors: Adrian Lopresti, Stephen Smith, Lixin Ding, Yanmei Li, and Peinan Zhang. Click here for a link to the article

The effects of lutein/ zeaxanthin (Lute-gen®) on eye health, eye strain, sleep quality, and attention in high electronic screen users: a randomized, double-blind, placebo-controlled study. Front. Nutr. 2025, Volume 12. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article

A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (Holixer) on stress, mood, and sleep in adults experiencing stress. Frontiers in Nutrition. September 2022. Authors: Adrian Lopresti, Stephen Smith, Alexandra Metse and Peter Drummond. Click here for a link to the article

An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study. Sleep Medicine. October 2021. Authors: Adrian Lopresti, Stephen Smith, and Peter Drummond. Click here for a link to the article

Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study. Journal of Functional Foods. October 2021. Authors: Adrian Lopresti, Stephen Smith, Sinan Ali, Alexandra Metse, John Kalns, and Peter Drummond. Click here for a link to the article

Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. Journal of Clinical Sleep Medicine. June 2020. Authors: Adrian Lopresti, Stephen Smith, Alexandra Metse, and Peter Drummond. Click here for a link to the article

The Effects of a Bacopa monnieri Extract (Bacumen®) on Cognition, Stress, and Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Clin Drug Investig. 2025 Jul;45(12):967-982. Authors: Adrian Lopresti and Stephen Smith Click here for a link to the article

Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study. J Psychoactive Drugs. 2024 Nov 5:1-13. Authors: Sanjiv Kale, Adrian Lopresti, Ravleen Suri, et al. Click here for a link to the article

Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. Nov 2023. Authors: Stephen Smith, Adrian Lopresti, and Timothy Fairchild. Click here for a link to the article

An examination into the mental and physical effects of a saffron extract (affron®) in recreationally-active adults: A randomized, double-blind, placebo-controlled study. Journal of the International Society of Sports Nutrition. June 2022. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article

Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study. Journal of Functional Foods. October 2021. Authors: Adrian Lopresti, Stephen Smith, Sinan Ali, Alexandra Metse, John Kalns, and Peter Drummond. Click here for a link to the article

A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males. American Journal of Men's Health. March 2019. Authors: Adrian Lopresti, Peter Drummond, and Stephen Smith. Click here for a link to the article

Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study. BMC Complementary Medicine and Therapies. January 2021. Authors: Adrian Lopresti, Stephen Smith, Alethea Rea, and Shavon Jackson-Michel. Click here for a link to the article

A poly-herbal blend (Herbagut®) on adults presenting with gastrointestinal complaints: a randomised, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018 Mar 20;18(1):98. Authors: Adrian Lopresti, Hemant Gupta, & Stephen Smith  Click here for a link to the article

The effects of lutein/ zeaxanthin (Lute-gen®) on eye health, eye strain, sleep quality, and attention in high electronic screen users: a randomized, double-blind, placebo-controlled study. Front. Nutr. 2025, Volume 12. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article

An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. June 2024. Authors: Adrian Lopresti, Stephen Smith, Melissa Riggs, et al. Click here for a link to the article

An Investigation into the Effects of a Curcumin Extract (Curcugen®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study. Nutrients 2022, 14(1), 41. Authors: Adrian Lopresti, Stephen Smith, Shavon Jackson-Michel, and Timothy Fairchild. Click here for a link to the article

An Examination into the Safety and Efficacy of Khapregesic®, a Khaya Senegalensis Preparation, on Women Experiencing Menstrual Pain and Menstrual Distress: A Randomized, Double-Blind, Placebo-Controlled Trial. International Journal of Women's Health. July 2025. Authors: Adrian L Lopresti, Stephen Smith, & Frederick Ferdinands. 17:2025-2038. Click here for a link to the article

The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. Journal of Menopausal Medicine. August 2021. Authors: Adrian Lopresti and Stephen Smith. Click here for a link to the article

A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males. American Journal of Men's Health. March 2019. Authors: Adrian Lopresti, Peter Drummond, and Stephen Smith. Click here for a link to the article

Examining the associations between testosterone and biomarkers as men age. Am J Hum Biol. Nov 2023. Authors: Stephen Smith, Daniel Bekele, Adrian Lopresti, & Timothy Fairchild

The effects of alcohol on testosterone synthesis in men: a review. March 2023 Authors: Stephen Smith, Adrian Lopresti, Timothy Fairchild

Potential Role of Curcumin for the Treatment of Major Depressive Disorder. CNS Drugs. Feb 2022. Authors: Adrian Lopresti

Examining the effects of calorie restriction on testosterone concentrations in men: a systematic review and meta-analysis. Nutr Rev. April 2022. Authors: Stephen Smith, Shaun Teo, Adrian Lopresti, Brody Heritage, Timothy Fairchild

Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials. Nutr Neurosci. August 2022. Authors: Adrian Lopresti, Stephen Smith, Peter Drummond

Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review. Adv Nutr. June 2021. Authors: Stephen Smith, Adrian Lopresti, Shaun Teo, Timothy Fairchild 

Herbal treatments for migraine: A systematic review of randomised-controlled studies. Phytother Res. October 2020. Authors Adrian Lopresti, Stephen Smith, & Peter Drummond

Association between Micronutrients and Heart Rate Variability: A Review of Human Studies. Adv Nutr. May 2020. Authors: Adrian Lopresti

The Effects of Psychological and Environmental Stress on Micronutrient Concentrations in the Body: A Review of the Evidence. Adv Nutr. January 2020. Authors: Adrian Lopresti

It is time to investigate integrative approaches to enhance treatment outcomes for depression? Med Hypotheses. May 2019. Authors: Adrian Lopresti

The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects? Adv Nutr. January 2018. Authors: Adrian Lopresti

Cognitive behaviour therapy and inflammation: A systematic review of its relationship and the potential implications for the treatment of depression. Aust N Z J Psychiatry. June 2017. Authors: Adrian Lopresti

Curcumin for neuropsychiatric disorders: a review of in vitro, animal and human studies. J Psychopharmacol. March 2017. Authors: Adrian Lopresti

Salvia (Sage): A Review of its Potential Cognitive-Enhancing and Protective Effects. Drugs R D. March 2017. Authors: Adrian Lopresti

Diet and Bipolar Disorder: A Review of Its Relationship and Potential Therapeutic Mechanisms of Action. J Altern Complement Med. December 2015. Authors: Adrian Lopresti & Felice Jacka

A review of nutrient treatments for paediatric depression. J Affect Disord. August 2015. Authors: Adrian Lopresti

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies. Atten Defic Hyperact Disord. December 2015. Authors: Adrian Lopresti

Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol. Nov 2014. Authors: Adrian Lopresti & Peter Drummond

A review of peripheral biomarkers in major depression: the potential of inflammatory and oxidative stress biomarkers. Prog Neuropsychopharmacol Biol Psychiatry. January 2014. Authors: Adrian Lopresti, Garth Maker, Sean Hood, Peter Drummond

Obesity and psychiatric disorders: commonalities in dysregulated biological pathways and their implications for treatment. Prog Neuropsychopharmacol Biol Psychiatry. August 2013. Authors: Adrian Lopresti & Peter Drummond

A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise. J Affect Disord. May 2013. Authors: Adrian Lopresti, Sean Hood, Peter Drummond

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects. J Psychopharmacol. December 2012. Authors: Adrian Lopresti, Sean Hood, Peter Drummond